Abstract #3123

Characterization of 3AM diffusion MRI phantoms via microscopy, and phase-contrast micro-CT

Farah Mushtaha^1,2, Tristan K. Kuehn^1,3, Omar El-Deeb⁴, Seyed A. Rohani³, Luke W. Helpard³, Hanif Ladak^2,3,5, Amanda Moehring⁶, Corey A. Baron^1,2,3,7, and Ali R. Khan^1,2,3,7

¹Robarts Research Institute, London, ON, Canada, ²Medical Biophysics, Schulich School of Medicine and Dentistry, Western University, London, ON, Canada, ³School of Biomedical Engineering, Western University, London, ON, Canada, ⁴Neuroscience, Western University, London, ON, Canada, ⁵Department of Electrical and Computer Engineering, Western University, London, ON, Canada, ⁶Biology, Western University, London, ON, Canada, ⁷The Brain and Mind Institute, Western University, London, ON, Canada

Validating diffusion MRI (dMRI) representations and models of brain tissue is challenging because there is no reference ground-truth for in vivo scans. We investigate the microstructural characteristics of 3D printed axon-mimetic (3AM) phantoms as a dMRI validation tool using fluorescence microscopy and phase-contrast micro computed tomography (micro-CT). Both microscopy and micro-CT yielded pore diameters of ~ 8 μm. We constructed a 2-compartment microstructural model using microscopy and micro-CT data to simulate 3AM dMRI scans, and compared the observed metrics from in-vivo scans and simulation data.

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