Neurodegenerative diseases such as Alzheimer, Parkinson, and Multiple sclerosis are often linked to abnormal changes in lipids and iron. Lipids are the main components of any membrane, including myelin, and iron is an essential brain’s trophic. The interaction of lipids and iron with water protons is considered to be a major contributor to the brain’s MRI signals. Here we examine the combined effects of the iron and lipid compositions on quantitative MRI parameters using a novel phantom system. We quantitatively characterize the R2* dependence on lipid and iron concentrations.
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