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Abstract #3124

A phantom system for evaluating the effect of lipid and iron composition on qMRI parameters

Rona Shaharabani1, Shir Filo1, Oshrat Shtangel1, and Aviv Mezer1
1The Edmond and Lily Safra Center for Brain Science, The Hebrew University of Jerusalem, Jerusalem, Israel, Jerusalem, Israel

Neurodegenerative diseases such as Alzheimer, Parkinson, and Multiple sclerosis are often linked to abnormal changes in lipids and iron. Lipids are the main components of any membrane, including myelin, and iron is an essential brain’s trophic. The interaction of lipids and iron with water protons is considered to be a major contributor to the brain’s MRI signals. Here we examine the combined effects of the iron and lipid compositions on quantitative MRI parameters using a novel phantom system. We quantitatively characterize the R2* dependence on lipid and iron concentrations.

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