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Abstract #3135

The effect of common resting-state fMRI preprocessing steps on the signal power spectrum

Jacob J.L. Matthews1, Jillian Krotz1, and J. Jean Chen1,2
1Rotman Research Institute, Baycrest, Toronto, ON, Canada, 2Medical Biophysics, University of Toronto, Toronto, ON, Canada

In resting-state functional MRI (rs-fMRI), the outcome measures, such as the amplitude of low-frequency fluctuation and functional connectivity, depend on the preprocessing steps applied. The mechanisms by which these steps modulate rs-fMRI outcomes are unclear, although it has long been established that the frequency composition of the rs-fMRI signal influences functional connectivity and related measures. In this work, we demonstrate the effect of commonly used preprocessing steps on rs-fMRI spectra, showing the potential interactions between these steps and cardiac/respiratory frequencies.

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