Abstract #3154

KIBRA rs17070145 interacts with gender on brain gray matter volume and functional connectivity density in healthy young adults

Junxia Wang¹, Sichu Wu², Jiaming Lu¹, Jilei Zhang³, Zhao Qing^1,4, and Bing Zhang¹

¹Department of Radiology, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University, Nanjing, China, ²The Affiliated Brain Hospital of Nanjing Medical University, Nanjing, China, ³Philips Healthcare, Shanghai, China, ⁴Institute for Brain Sciences, Nanjing University, Nanjing, China

KIBRA rs17070145 and gender have been found to have associations with episodic memory. However, the underlying mechanisms and their combined effects on the brain gray matter volume (GMV) and functional connectivity density (FCD) remain unknown. This study found that KIBRA gene interacted with gender on the GMV and long-range FCD (lrFCD) using voxel-based morphometry (VBM) analysis. These findings underscored the importance of KIBRA and gender interactions as regards to brain structural and functional alterations, which is crucial for the neurobiological understanding of episodic memory.

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