Abstract #3155

Global Connectivity of the Cerebellum Predicts Slow Wave Sleep Improvement: A Randomized Controlled Acupuncture Trial

Ran Pang^1,2, Xi Wu³, Yuchen Chi⁴, Rommy Elyan⁵, Xianke Luo⁶, Zhigang Chen⁶, Qingxian Yang², Karunanayaka Prasanna⁷, and Kuncheng Li⁸

¹Department of Radiology, Dongfang Hospital, Beijing University of Chinese Medicine, Beijing, China, ²Department of Neurosurgery, Pennsylvania State University College of Medicine, Hershey, PA, United States, ³Department of Acupuncture, Dongfang Hospital, Beijing University of Chinese Medicine, Beijing, China, ⁴Department of Otolaryngology, Dongfang Hospital, Beijing University of Chinese Medicine, Beijing, China, ⁵Department of Radiology, Pennsylvania State University College of Medicine, PA, USA, Hershey, PA, United States, ⁶Department of Neurology, Dongfang Hospital, Beijing University of Chinese Medicine, Beijing, China, ⁷Department of Radiology, Pennsylvania State University College of Medicine, Hershey, PA, United States, ⁸Department of Radiology, Xuanwu Hospital, Capital Medical University, Beijing, China

The cerebellum is an important brain structure for sleep. We identified a global connectivity mechanism with which the cerebellum coordinates and controls sleep-related networks. Global connectivity of the cerebellum showed a highly selective relationship with individual differences in slow-wave sleep (SWS) improvements, after both verum and sham acupuncture treatments. Cerebellar connectivity with the thalamus differed significantly between treatment types. Highlighting its ability to distinguish amongst processes central to sham and verum treatments. Our findings suggest a particular architecture for the cerebellum: a flexible global hub with a brain-wide influence, supporting both circadian rhythms and sleep homeostasis.

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