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Abstract #3163

Changes in Gray Matter Volume and Functional Connectivity of Obese Females with Acupuncture and Diet Control Therapy: Placebo Effect or Not?

Jiawei Han1, Hui Zhang2, Junqi Xu2, Fanwen Wang2, Jian Gao3,4, Weibo Chen5, Hongmei Yan6, and He Wang1,2
1Human Phenome Institute, Fudan University, Shanghai, China, 2Institute of Science and Technology for Brain-Inspired Intelligence, Fudan University, Shanghai, China, 3Department of Nutrition, Zhongshan Hospital, Fudan University, Shanghai, China, 4Center of Clinical Epidemiology and Evidence-based Medicine, Fudan University, Shanghai, China, 5Philips Healthcare, Shanghai, China, 6Department of Endocrinology, Zhongshan Hospital, Fudan University, Shanghai, China

Weight loss is a stressful process for obese women, and effects on their physiology and psychology vary from different methods to lose weight. Acupuncture is a relatively easy and effective way, but its mechanism is still unclear. To investigate these phenomena, 16 obese females were recruited to participate in this MRI study. Our results show that the weight loss methods of acupuncture and diet control increase gray matter volume in different regions, and the influence of acupuncture for functional connectivity might be lighter, which is likely to reveal the acupuncture principles and the psychological impact on patients.

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