Abstract #3163

Changes in Gray Matter Volume and Functional Connectivity of Obese Females with Acupuncture and Diet Control Therapy: Placebo Effect or Not?

Jiawei Han¹, Hui Zhang², Junqi Xu², Fanwen Wang², Jian Gao^3,4, Weibo Chen⁵, Hongmei Yan⁶, and He Wang^1,2

¹Human Phenome Institute, Fudan University, Shanghai, China, ²Institute of Science and Technology for Brain-Inspired Intelligence, Fudan University, Shanghai, China, ³Department of Nutrition, Zhongshan Hospital, Fudan University, Shanghai, China, ⁴Center of Clinical Epidemiology and Evidence-based Medicine, Fudan University, Shanghai, China, ⁵Philips Healthcare, Shanghai, China, ⁶Department of Endocrinology, Zhongshan Hospital, Fudan University, Shanghai, China

Weight loss is a stressful process for obese women, and effects on their physiology and psychology vary from different methods to lose weight. Acupuncture is a relatively easy and effective way, but its mechanism is still unclear. To investigate these phenomena, 16 obese females were recruited to participate in this MRI study. Our results show that the weight loss methods of acupuncture and diet control increase gray matter volume in different regions, and the influence of acupuncture for functional connectivity might be lighter, which is likely to reveal the acupuncture principles and the psychological impact on patients.

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