The relaxivity contrast imaging parameter, TRATE (tissue transverse relaxivity at tracer equilibrium), has been shown to decrease during ALS induced myofiber degradation, due to T1 and T2* effects that occur when the contrast agent distributes around myofibers. The goal of this study is to expand a validated computational method to investigate the biophysical basis of TRATE in muscles of ALS patients and to optimize RCI acquisition parameters.
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