Abstract #3168

Establishing a computational approach to investigate the biophysical basis of relaxivity contrast imaging in the context of muscle degeneration

Natenael B Semmineh¹, Sudarshan Ragunathan², Laura C Bell², and C Chad Quarles ²

¹Imaging Research, Barrow Neurological Institute rrow Neurological Institute, Phoenix, AZ, United States, ²Imaging Research, Barrow Neurological Institute, Phoenix, AZ, United States

The relaxivity contrast imaging parameter, TRATE (tissue transverse relaxivity at tracer equilibrium), has been shown to decrease during ALS induced myofiber degradation, due to T1 and T2* effects that occur when the contrast agent distributes around myofibers. The goal of this study is to expand a validated computational method to investigate the biophysical basis of TRATE in muscles of ALS patients and to optimize RCI acquisition parameters.

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