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Abstract #3167

Altered creatine kinase activity and mitochondrial oxidative capacity in muscular dystrophic mdx mice after repeated muscle contraction  

Kihwan Kim1, Yuning Gu1, Yuran Zhu1, Yudu Li2,3, Sherry Huang1, Zhi-Pei Liang 2,3, and Xin Yu1,4
1Biomedical Engineering, Case Western Reserve University, cleveland, OH, United States, 2Electrical and Computer Engineering, University of Illinois at Urbana-Champaign, Urbana, IL, United States, 3Beckman Institute for advanced Science and Technology, University of Illinois at Urbana-Champaign, Urbana, IL, United States, 4Case Center for Imaging Research, Case Western Reserve University, cleveland, OH, United States

This study investigated the creatine kinase activity and the effects of repeated muscle contraction on muscle metabolism in mdx mice, a mouse model for Duchenne Muscular Dystrophy (DMD). Using phosphorous-31 (31P) magnetic resonance fingerprinting and dynamic 31P magnetic resonance spectroscopy, we observed a significant decrease in creatine kinase (CK) reaction rate in mdx mice compared to control mice. Decrease in phosphocreatine (PCr) recovery rate after its depletion by stimulation-induced muscle contraction was also observed in mdx mice. These findings suggest altered mitochondrial function in mdx mice.

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