Abstract #3167

Altered creatine kinase activity and mitochondrial oxidative capacity in muscular dystrophic mdx mice after repeated muscle contraction

Kihwan Kim¹, Yuning Gu¹, Yuran Zhu¹, Yudu Li^2,3, Sherry Huang¹, Zhi-Pei Liang ^2,3, and Xin Yu^1,4

¹Biomedical Engineering, Case Western Reserve University, cleveland, OH, United States, ²Electrical and Computer Engineering, University of Illinois at Urbana-Champaign, Urbana, IL, United States, ³Beckman Institute for advanced Science and Technology, University of Illinois at Urbana-Champaign, Urbana, IL, United States, ⁴Case Center for Imaging Research, Case Western Reserve University, cleveland, OH, United States

This study investigated the creatine kinase activity and the effects of repeated muscle contraction on muscle metabolism in mdx mice, a mouse model for Duchenne Muscular Dystrophy (DMD). Using phosphorous-31 (³¹P) magnetic resonance fingerprinting and dynamic ³¹P magnetic resonance spectroscopy, we observed a significant decrease in creatine kinase (CK) reaction rate in mdx mice compared to control mice. Decrease in phosphocreatine (PCr) recovery rate after its depletion by stimulation-induced muscle contraction was also observed in mdx mice. These findings suggest altered mitochondrial function in mdx mice.

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