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Abstract #3166

Effect of Eddy Current Correction on Muscle Diffusion Measurements

Xingyu Zhou1,2, Melissa T. Hooijmans1,3, Crystal L. Coolbaugh1, Mark K. George1, and Bruce M. Damon1,2,4,5
1Vanderbilt University Institute of Imaging Science, Nashville, TN, United States, 2Department of Biomedical Engineering, Vanderbilt University, Nashville, TN, United States, 3Department of Radiology & Nuclear Medicine, Amsterdam Movement Sciences, Amsterdam University Medical Center, Amsterdam, Netherlands, 4Department of Radiology & Radiological Sciences, Vanderbilt University Medical Center, Nashville, TN, United States, 5Department of Molecular Physiology & Biophysics, Vanderbilt University Medical Center, Nashville, TN, United States

Diffusion-tensor MRI (DTMRI) fiber tractography is a useful tool for reconstructing the structure of white matter tracts, nerves, and muscles. Eddy current correction is recognized as an important step in analysis of neuronal DTMRI data, while its effect on muscle DTMRI analysis has not been studied systematically. In this work we describe a preliminary comparison of muscle diffusion tensor imaging results with and without including eddy current correction in the pre-processing steps, including the morphological mismatch with anatomical image, the estimation of eigenvalues and fractional anisotropy, and the distribution of the first eigenvector within the selected muscle.

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