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Abstract #3165

Dynamic MR imaging of muscle contraction during electrical stimulation in facioscapulohumeral muscular dystrophy: a longitudinal study

Xeni Deligianni1,2, Francesco Santini1,2, Matteo Paoletti3, Francesca Solazzo3, Niels Bergsland4,5, Giovanni Savini3, Arianna Faggioli3, Giancarlo Germani3, Mauro Monforte6, Giorgio Tasca6, Enzo Ricci6, and Anna Pichiecchio3,7
1Department of Radiology/ Division of Radiological Physics, University Hospital of Basel, Basel, Switzerland, 2Biomedical Engineering, University of Basel, Allschwil, Switzerland, 3Advanced Imaging and Radiomics Center, Neuroradiology Department, IRCCS Mondino Foundation, Pavia, Italy, 4Buffalo Neuroimaging Analysis Center, Department of Neurology, Buffalo Neuroimaging Analysis Center, Department of Neurology, Jacobs School of Medicine and Biomedical Sciences, Buffalo, NY, United States, 5IRCCS, Fondazione Don Carlo Gnocchi ONLUS, Milan, Italy, 6Unità€ Operativa Complessa di Neurologia, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy, 7Department of Brain and Behavioral Sciences, University of Pavia, Pavia, Italy

Quantitative muscle MRI (T2&fat mapping) is progressively more used to assess disease involvement in muscle disorders, but in a static way, with dynamic assessment usually performed by clinical and instrumental examinations. To characterize muscle deformation we applied dynamic MRI synchronized with neuromuscular electrical stimulation evaluating the quadriceps muscles in 34 ambulatory subjects affected by facioscapulohumeral muscular dystrophy (FSHD) and ten healthy controls, longitudinally. Maximum values and rates of the strain differed between the two groups. Our results suggest that the evaluation of muscle ability to contract could be potentially used to monitor the evolution of muscle involvement in FSHD.

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