Abstract #3165

Dynamic MR imaging of muscle contraction during electrical stimulation in facioscapulohumeral muscular dystrophy: a longitudinal study

Xeni Deligianni^1,2, Francesco Santini^1,2, Matteo Paoletti³, Francesca Solazzo³, Niels Bergsland^4,5, Giovanni Savini³, Arianna Faggioli³, Giancarlo Germani³, Mauro Monforte⁶, Giorgio Tasca⁶, Enzo Ricci⁶, and Anna Pichiecchio^3,7

¹Department of Radiology/ Division of Radiological Physics, University Hospital of Basel, Basel, Switzerland, ²Biomedical Engineering, University of Basel, Allschwil, Switzerland, ³Advanced Imaging and Radiomics Center, Neuroradiology Department, IRCCS Mondino Foundation, Pavia, Italy, ⁴Buffalo Neuroimaging Analysis Center, Department of Neurology, Buffalo Neuroimaging Analysis Center, Department of Neurology, Jacobs School of Medicine and Biomedical Sciences, Buffalo, NY, United States, ⁵IRCCS, Fondazione Don Carlo Gnocchi ONLUS, Milan, Italy, ⁶Unità Operativa Complessa di Neurologia, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy, ⁷Department of Brain and Behavioral Sciences, University of Pavia, Pavia, Italy

Quantitative muscle MRI (T2&fat mapping) is progressively more used to assess disease involvement in muscle disorders, but in a static way, with dynamic assessment usually performed by clinical and instrumental examinations. To characterize muscle deformation we applied dynamic MRI synchronized with neuromuscular electrical stimulation evaluating the quadriceps muscles in 34 ambulatory subjects affected by facioscapulohumeral muscular dystrophy (FSHD) and ten healthy controls, longitudinally. Maximum values and rates of the strain differed between the two groups. Our results suggest that the evaluation of muscle ability to contract could be potentially used to monitor the evolution of muscle involvement in FSHD.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.