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Abstract #3214

Comparison of UTE 1H lung MRI with quantitative CT and hyperpolarized 129Xe diffusion-weighted MRI in IPF

Ho-Fung Chan1, James A Eaden1, Nicholas D Weatherley1, Kevin Johnson2, Guilhem J Collier1, Madhwesha Rao1, Graham Norquay1, Jody Bray1, Smitha Rajaram1, Andrew J Swift1, Ronald A Karwoski3, Brian J Bartholmai3, Stephen M Bianchi4, and Jim M Wild1
1Infection, Immunity and Cardiovascular Disease, University of Sheffield, Sheffield, United Kingdom, 2Radiology and Medical Physics, University of Wisconsin, Madison, WI, United States, 3Biomedical Imaging Resource, Mayo Clinic, Rochester, MN, United States, 4Academic Directorate of Respiratory Medicine, Sheffield Teaching Hospitals NHS Foundation Trust, Sheffield, United Kingdom

A simple signal density-based analysis of UTE 1H MRI was compared to hyperpolarized 129Xe diffusion-weighted (DW)-MRI and CALIPER CT in twelve idiopathic pulmonary fibrosis (IPF) patients at baseline and after 1 year. A statistically significant correlation between the normalized UTE signal and CALIPER interstitial lung disease percentage was observed in the lower lung zone. Trends between UTE signal and 129Xe DW-MRI metrics in the lower zone was observed, and no significant longitudinal change in UTE MRI signal was observed. UTE MRI signal is sensitive to IPF lung parenchyma changes and may demonstrate sensitivity to longitudinal changes in a larger cohort.

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