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Abstract #3218

Imaging the interplay of notch-DLL4 expression with pulmonary radiation injury using dynamic contrast enhanced ultrashort echo time imaging  

El-Sayed H Ibrahim1, Abdul Parchur1, Brian Fish1, Meetha Medhora1, and Amit Joshi1
1Medical College of Wisconsin, Milwaukee, WI, United States

Lung injury after exposure to high-dose radiation during cancer treatment has been well described. Our goal in this study is to develop minimally invasive biomarkers for predicting radiation-induced lung injury and assess the role of DLL4 expression in response to radiation injury. We presented a non-invasive UTE-based DCE MRI method for in-vivo quantification of irradiation-induced vascular perfusion and permeability early changes in lungs using two rat models which only differ in 3rd chromosome and DLL4 expression on endothelium. Such knowledge is crucial for accurately evaluating the efficacy of radioprotectors and therapeutic agents, and for monitoring individuals with survivable radiation injury.

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