Several methods of mapping regional ventilation from multi-inflation 1H-MRI have been proposed, potentially transforming 1H-MRI from a structural modality into one that can image and quantify pulmonary ventilation. However, their physiological accuracy and sensitivity to lung inflation level is an ongoing research question. Here, we compare surrogates of regional ventilation, derived from non-contrast inspiratory and expiratory breath-hold 3D gradient-echo 1H-MRI with hyperpolarized 3He-MRI, pulmonary functions tests and multiple-breath washout in a cohort of cystic fibrosis patients with a range of disease severity and age. We observed moderate to strong correlations with all lung function measures and 3He-MRI.
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