Abstract #3221

Same-session Repeatability of Hyperpolarized 129Xe MRI Gas Uptake Measures in Healthy Subjects and Subjects with COPD

William J Garrison¹, G Wilson Miller^1,2, Kun Qing², Y Michael Shim³, Jaime F Mata², Mu He³, Talissa A Altes⁴, Joanne M Cassani⁴, Sarah E Struchen², Roselove N Nunoo-Asare², Nicholas J Tustison², Alan M Ropp², and John P Mugler III^1,2

¹Biomedical Engineering, University of Virginia, Charlottesville, VA, United States, ²Radiology and Medical Imaging, University of Virginia, Charlottesville, VA, United States, ³Medicine, University of Virginia, Charlottesville, VA, United States, ⁴Radiology, University of Missouri, Columbia, MO, United States

Same-session repeatability of quantitative measures of gas uptake derived from MRI of inhaled hyperpolarized ¹²⁹Xe was assessed in healthy and COPD subjects, as well as the impact of scan-to-scan lung volume differences on measured gas uptake. Strong tissue-to-gas and RBC-to-tissue repeatability was found in same-day dissolved-phase ¹²⁹Xe MRI scans performed at one-third of forced vital capacity, and regressing out scan-to-scan lung volume changes improved repeatability further. COPD subjects displayed similar or better repeatability when compared with healthy subjects.

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