19F-MRI of inhaled perfluoropropane (PFP) permits regional assessment of pulmonary ventilation. Dynamic multi-breath PFP wash-in and wash-out images were acquired in one healthy volunteer and two patients with chronic obstructive pulmonary disease (COPD) during short successive breath holds, using a repeated 3D 19F-SPGR sequence accelerated with compressed sensing. Resultant image quality achieved in each 7.5s compressed sensing acquisition dynamic was sufficient for segmentation and permitted visualisation of a case of gas trapping secondary to apical predominant emphysema. A strong negative correlation between regional wash-in and wash-out rates and spirometric indices was measured.
This abstract and the presentation materials are available to members only; a login is required.