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Abstract #3222

Accelerated dynamic 19F-MRI of inhaled perfluoropropane for quantitative regional assessment of gas wash-in biomarkers in patients with COPD

Mary A. Neal1,2, Benjamin J. Pippard1,2, Kieren G. Hollingsworth1,2, A. John Simpson2, and Peter E. Thelwall1,2
1Newcastle Magnetic Resonance Centre, Newcastle University, Newcastle upon Tyne, United Kingdom, 2Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, United Kingdom

19F-MRI of inhaled perfluoropropane (PFP) permits regional assessment of pulmonary ventilation. Dynamic multi-breath PFP wash-in and wash-out images were acquired in one healthy volunteer and two patients with chronic obstructive pulmonary disease (COPD) during short successive breath holds, using a repeated 3D 19F-SPGR sequence accelerated with compressed sensing. Resultant image quality achieved in each 7.5s compressed sensing acquisition dynamic was sufficient for segmentation and permitted visualisation of a case of gas trapping secondary to apical predominant emphysema. A strong negative correlation between regional wash-in and wash-out rates and spirometric indices was measured.

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