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Abstract #3289

Comparison of lung T1 mapping using variable flip angle and Look-Locker techniques

Laura Saunders1, Paul J. C. Hughes1, James Eaden1, Andy J Swift1, Stephen Bianchi2, and Jim M Wild1
1Infection Immunity and Cardiovascular Disease, University of Sheffield, Sheffield, United Kingdom, 2Sheffield Teaching Hospitals NHS, Sheffield, United Kingdom

Lung T1 is sensitive to lung pathology, tissue and perfusion, and can be used to the calculation of quantitative DCE perfusion metrics. However, no comparisons have been made of common MRI T1 mapping sequences in the human lung. The aim of this work was to compare Look-Locker and variable flip angle T1 mapping sequences in phantoms and in vivo, in the lung, liver and blood. T1 measured in the phantom, blood and liver was significantly lower when measured using a Look-Locker acquisition than VFA, whereas lung T1 was significantly higher when measured using Look-Locker acquisition than when measured using VFA.

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