Abstract #3296

Transversal Relaxometry of a Mixture of Iron Compounds at Different Concentrations

Arthur Peter Wunderlich^1,2, Eva Leithner¹, Richard Fiedler³, Meinrad Beer¹, Stefan Andreas Schmidt¹, and Mika Lindén³

¹Dept. of Diagnostic Radiology, Ulm University, Medical Center, Ulm, Germany, ²Section for Experimental Radiology, Ulm University, Medical Center, Ulm, Germany, ³Institute for Inorganic Chemistry II, Ulm University, Ulm, Germany

Liver R₂* determined with a breath hold GRE sequence is commonly used to address liver iron content in vivo. However, iron occurs in the body bound to various chemical substances. To study influence of chemical composition on R₂* on a clinical MRI scanner, we scanned mixtures of two iron compounds, polymer coated nanoparticles on the one hand and diluted Fe³⁺ ions on the other, at different concentrations of both compounds. We found that the relaxivity of one compound depended on the concentration of the other, suggesting that the interactions between compounds are more complex than previously assumed.

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