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Abstract #3296

Transversal Relaxometry of a Mixture of Iron Compounds at Different Concentrations

Arthur Peter Wunderlich1,2, Eva Leithner1, Richard Fiedler3, Meinrad Beer1, Stefan Andreas Schmidt1, and Mika Lindén3
1Dept. of Diagnostic Radiology, Ulm University, Medical Center, Ulm, Germany, 2Section for Experimental Radiology, Ulm University, Medical Center, Ulm, Germany, 3Institute for Inorganic Chemistry II, Ulm University, Ulm, Germany

Liver R2* determined with a breath hold GRE sequence is commonly used to address liver iron content in vivo. However, iron occurs in the body bound to various chemical substances. To study influence of chemical composition on R2* on a clinical MRI scanner, we scanned mixtures of two iron compounds, polymer coated nanoparticles on the one hand and diluted Fe3+ ions on the other, at different concentrations of both compounds. We found that the relaxivity of one compound depended on the concentration of the other, suggesting that the interactions between compounds are more complex than previously assumed.

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