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Abstract #3297

Hepatic iron quantification using a Free-breathing 3D Radial Dixon technique and validation with a 2D GRE biopsy calibration

Shawyon Chase Rohani1,2, Cara Morin1, Xiaodong Zhong3, Stephan Kannengiesser4, Joseph Holtrop1, Ayaz Khan1, Ralf Loeffler1,5, Claudia Hillenbrand1,5, Jane Hankins6, and Aaryani Tipirneni Sajja1,2
1Department of Diagnostic Imaging, St. Jude Children's Research Hospital, Memphis, TN, United States, 2Department of Biomedical Engineering, The University of Memphis, Memphis, TN, United States, 3Siemens Medical Solutions USA, Inc., Los Angeles, CA, United States, 4MR Application Development, Siemens Healthcare, Erlangen, Germany, 5University of New South Wales, Sydney, Australia, 6Department of Hematology, St. Jude Children's Research Hospital, Memphis, TN, United States

Radial acquisitions are less motion sensitive and a viable alternative in patients unable to breath-hold. This study investigates a free-breathing 3D Radial Dixon technique to assess HIC by validating with 3D Cartesian Dixon and biopsy-calibrated 2D GRE method. All three acquisitions showed excellent correlation with each other. The free-breathing 3D Radial Dixon produced sharper images whereas the 2D GRE and 3D VIBE Cartesian-based techniques exhibited motion artifacts and a slight underestimation in R2* values compared to 3D Radial VIBE likely due to motion artifacts.

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