Abstract #3297

Hepatic iron quantification using a Free-breathing 3D Radial Dixon technique and validation with a 2D GRE biopsy calibration

Shawyon Chase Rohani^1,2, Cara Morin¹, Xiaodong Zhong³, Stephan Kannengiesser⁴, Joseph Holtrop¹, Ayaz Khan¹, Ralf Loeffler^1,5, Claudia Hillenbrand^1,5, Jane Hankins⁶, and Aaryani Tipirneni Sajja^1,2

¹Department of Diagnostic Imaging, St. Jude Children's Research Hospital, Memphis, TN, United States, ²Department of Biomedical Engineering, The University of Memphis, Memphis, TN, United States, ³Siemens Medical Solutions USA, Inc., Los Angeles, CA, United States, ⁴MR Application Development, Siemens Healthcare, Erlangen, Germany, ⁵University of New South Wales, Sydney, Australia, ⁶Department of Hematology, St. Jude Children's Research Hospital, Memphis, TN, United States

Radial acquisitions are less motion sensitive and a viable alternative in patients unable to breath-hold. This study investigates a free-breathing 3D Radial Dixon technique to assess HIC by validating with 3D Cartesian Dixon and biopsy-calibrated 2D GRE method. All three acquisitions showed excellent correlation with each other. The free-breathing 3D Radial Dixon produced sharper images whereas the 2D GRE and 3D VIBE Cartesian-based techniques exhibited motion artifacts and a slight underestimation in R₂^* values compared to 3D Radial VIBE likely due to motion artifacts.

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