Abstract #3301

Ultrashort echo time R1ρ for detection of rat liver iron overload at 11.7T MRI

Qianfeng Wang¹, Hong Xiao², He Wang^1,3, and Fuhua Yan²

¹Institute of Science and Technology for Brain-Inspired Intelligence, Fudan University, Shanghai, China, ²Department of Radiology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China, ³Human Phenome Institute, Fudan University, Shanghai, China, Shanghai, China

In this study, R1ρ images of 24 rat liver samples were acquired with 2D UTE-R1ρ pulse sequences. The results showed that mean R1ρ values displayed dispersion, with decrease in R1ρ at higher FSLs. Spearman’s correlation analysis (two-tailed) indicated that the R1ρ values were significantly associated with liver iron concentration at all 6 spin-lock frequencies (all r > 0.8 and all P < 0.001).

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