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Abstract #3301

Ultrashort echo time R1ρ for detection of rat liver iron overload at 11.7T MRI

Qianfeng Wang1, Hong Xiao2, He Wang1,3, and Fuhua Yan2
1Institute of Science and Technology for Brain-Inspired Intelligence, Fudan University, Shanghai, China, 2Department of Radiology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China, 3Human Phenome Institute, Fudan University, Shanghai, China, Shanghai, China

In this study, R1ρ images of 24 rat liver samples were acquired with 2D UTE-R1ρ pulse sequences. The results showed that mean R1ρ values displayed dispersion, with decrease in R1ρ at higher FSLs. Spearman’s correlation analysis (two-tailed) indicated that the R1ρ values were significantly associated with liver iron concentration at all 6 spin-lock frequencies (all r > 0.8 and all P < 0.001).

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