Abstract #3313

Efficient Phase Cycling Strategy for High Resolution Three-Dimensional GRE Quantitative Mapping

Qi Peng¹, Can Wu^2,3, Jee Hun Kim^4,5, and Xiaojuan Li^4,5,6

¹Department of Radiology, Albert Einstein College of Medicine, Bronx, NY, United States, ²Department of Medical Physics, Memorial Sloan Kettering Cancer Center, New York, NY, United States, ³Philips Healthcare, Andover, MA, United States, ⁴Program of Advanced Musculoskeletal Imaging (PAMI), Cleveland Clinic, Cleveland, OH, United States, ⁵Department of Biomedical Engineering, Cleveland Clinic, Cleveland, OH, United States, ⁶Department of Diagnostic Radiology, Cleveland Clinic, Cleveland, OH, United States

Magnetization-prepared gradient echo (MP-GRE) sequences have been commonly used for quantitative MRI in the literature to improve imaging speed. Paired acquisitions with RF phase-cycling could eliminate image blurring due to longitudinal relaxation and loss of MP contrast along the GRE readouts, with doubled scan time. This study introduces a novel unpaired phase cycling strategy to eliminate the time penalty with reduced sensitivity to B₀ field inhomogeneities for high resolution quantitative mapping in MP-GRE sequences. The feasibility and efficacy of this strategy were demonstrated in both phantom and human studies.

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