Tissue fat and spatially varying B1 inhomogeneities are known confounders of quantitative T1W(ater) mapping methods that use variable flip angle techniques. T1W measurements can be corrected for B1 heterogeneity, but this typically requires an additional B1 calibration acquisition both extending patient acquisition time and introducing image registration considerations. In this work we propose simultaneous estimation of B1, T1W, proton density fat-fraction and R2* using a three-pass approach using dual orthogonal RF pulses and multiple flip angles. The feasibility and noise performance of this proposed acquisition and fitting strategy are evaluated using Cramer-Rao Lower Bound analysis, simulations, and phantom experiments.
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