Quantitative MRI can precisely measure biomarkers for disease, such as liver hemochromatosis. R2* correlates with liver iron concentration (LIC), but data is scarce for 3T R2* mapping. The out-of-the box vendor provided sequences for quantitative R2* measurements do not precisely measure large R2* values in a standardized phantom. The discrepancy is greater at higher R2* values. This can lead to underestimates in LIC quantification for patients with severe hemochromatosis. R2* mapping from different MRI vendors may yield different results, and patient specific QA may be necessary for clinical utilization for quantitative R2* mapping.
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