Fabrizio Fasano1,2, John Evans3, Chloe Benson4, Yifei Wang4, Derek K Jones3,5, Alison Paul4, and Robert Turner6,7
1Siemens Healthcare Ltd, Camberly, United Kingdom, 2Siemens Healthcare GmbH, Erlangen, Germany, 3Cardiff University Brain Research Imaging Centre (CUBRIC), Cardiff University, Cardiff, United Kingdom, 4School of Chemistry, Cardiff University, Cardiff, United Kingdom, 5Mary McKillop Institute for Health Research, Faculty of Health Sciences, Australian Catholic University, Melbourne, Australia, 6Department of Neurophysics, Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany, 7Sir Peter Mansfield Imaging Centre, University of Nottingham, Nottingham, United Kingdom
Myeloarchitecture has a critical role in the specialisation of brain microcircuitry. It shapes network functions from small to large scale, and ultimately behaviour. We tested, on homemade Agar gel phantoms, the multi-shot inversion recovery slice shuffled EPI IR-MS-EPI approach recently proposed by Sanchez and co-workers (Proc. Intl. Soc. Mag. Reson. Med. 2018, 60). Our measurement results and the simulated performances of MS-IR-EPI showed a good reproducibility of the T1 maps and a preserved quality of its point spread function, when acquiring at higher-than 500μm in-plane resolution, making it suitable for assessing grey matter myelination process.