Abstract #3354

Oil-in-water emulsions for tissue simulation in magnetic resonance imaging: Determination of MR-properties of emulsifiers

Victor Fritz¹, Petros Martirosian¹, Jürgen Machann^1,2, Rolf Daniels³, and Fritz Schick¹

¹Section on Experimental Radiology, University of Tübingen, Tübingen, Germany, ²Institute for Diabetes Research and Metabolic Diseases of the Helmholtz Centre Munich at the University of Tübingen, Tübingen, Germany, ³Institute of Pharmaceutical Technology, University of Tübingen, Tübingen, Germany

The aim of this work was to develop stable and homogeneous oil-in-water emulsions for tissue simulation in MRI. For this purpose, three different emulsifiers (polysorbate 60, sodium dodecyl sulfate (SDS), and soy lecithin) were examined for their stabilizing ability. In addition, their potential impact on the MR-measurements was investigated. Sufficient stability can be achieved using both emulsifier, polysorbate and lecithin. Emulsions stabilized by SDS showed a visually lower stability. Due to its sufficient stabilizing ability, promising relaxometric properties (r_1,lecithin=0,11wt%^-1s^-1, r_2,lecithin =0,62wt%^-1s^-1), and no additional spectral resonances, lecithin is suggested as the preferred emulsifier for use in MRI.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.