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Abstract #3354

Oil-in-water emulsions for tissue simulation in magnetic resonance imaging: Determination of MR-properties of emulsifiers

Victor Fritz1, Petros Martirosian1, Jürgen Machann1,2, Rolf Daniels3, and Fritz Schick1
1Section on Experimental Radiology, University of Tübingen, Tübingen, Germany, 2Institute for Diabetes Research and Metabolic Diseases of the Helmholtz Centre Munich at the University of Tübingen, Tübingen, Germany, 3Institute of Pharmaceutical Technology, University of Tübingen, Tübingen, Germany

The aim of this work was to develop stable and homogeneous oil-in-water emulsions for tissue simulation in MRI. For this purpose, three different emulsifiers (polysorbate 60, sodium dodecyl sulfate (SDS), and soy lecithin) were examined for their stabilizing ability. In addition, their potential impact on the MR-measurements was investigated. Sufficient stability can be achieved using both emulsifier, polysorbate and lecithin. Emulsions stabilized by SDS showed a visually lower stability. Due to its sufficient stabilizing ability, promising relaxometric properties (r1,lecithin=0,11wt%-1s-1, r2,lecithin =0,62wt%-1s-1), and no additional spectral resonances, lecithin is suggested as the preferred emulsifier for use in MRI.

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