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Abstract #3357

A novel MRI phantom to study the fluid dynamics of the glymphatic system: a proof-of-concept study

Endre Grøvik1,2, Elisabeth Lysvik1, Robin Bugge1, Kyrre Emblem1, Trine Hjørnevik1, Svein-Are Vatnehol1, and Tryggve Storås1
1Oslo University Hospital, Oslo, Norway, 2University of South-Eastern Norway, Drammen, Norway

The proposed glymphatic system is hypothesized to be a waste-clearance system of the cerebrospinal fluid (CSF) through the perivascular and interstitial spaces of the brain. The details of this system, and its contribution to the delivery of nutrients and eliminating waste products, are yet to be established. Here we present a tailored MRI phantom to simulate the fluid dynamics of the CSF in the perivascular space. This glymphatic ultra-slow flow phantom facilitates testing of MRI flow measurements in a controlled environment, enabling optimization of MRI scan parameters to allow accurate measurements of glymphatic flow in the human brain.

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