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Abstract #3358

Reaching low-gadolinium concentration detection through sequences optimization on a dedicated phantom

Emilie Poirion1, Corentine Marie2, Marine Boudot de La Motte3, ChloƩ Dupont4, Jean-Claude Sadik1, and Julien Savatovsky1
1Hospital Foundation A. de Rothschild, Imaging department, Paris, France, PARIS, France, 2Sorbonne University, Paris Brain Institute, Paris, France, Paris, France, 3Hospital Foundation Rothschild,Neurology department, Paris, France, Paris, France, 4Hospital Foundation A. de Rothschild, Pharmaceutical department, Paris, France, PARIS, France

Gadolinium-enhanced imaging provides valuable information in clinical practice for the diagnosis of several diseases. Conventional sequences fail to detect low concentrations of gadolinium, such as those encountered in abnormal meninges. We designed a phantom containing 16 diluted gadobutrol tubes to compare and optimize sequences, based on normalized signal and contrast-to-noise ratio, for each gadolinium concentration. We performed a preliminary study comparing T1, FLAIR and FLAIR with optimized parameters on this phantom. The optimized FLAIR sequence shows an efficient detection of low concentrations, with a higher CNR than other sequences. Preliminary in-vivo experiment shows promising results for leptomeningeal abnomalities detection.

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