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Abstract #3365

Functional connectome of arousal and motor brainstem nuclei using 7 Tesla resting-state fMRI in living humans

Kavita Singh1, Simone Cauzzo1,2, Maria Guadalupe Garcia Gomar1, Matthew Stauder1, Nicola Vanello3, Claudio Passino2,4, and Marta Bianciardi1
1Brainstem Imaging Laboratory, Department of Radiology, Athinoula A. Martinos Center for Biomedical Imaging, Boston, MA, United States, 2Sant'Anna School of Advanced Studies, Institute of Life Sciences, Pisa, Italy, 3Dipartimento di Ingegneria dell’Informazione, University of Pisa, Pisa, Italy, 4Fondazione Toscana Gabriele Monasterio, Pisa, Italy

For a holistic understanding of sleep, arousal and associated motor processes, we investigated the resting-state functional connectivity of 18 arousal and motor brainstem nuclei in living humans by the use of high spatial-resolution 7 Tesla resting-state fMRI, as well as a recently developed in-vivo probabilistic atlas of these nuclei in standard space. Further, we verified the translatability of our brainstem connectome approach to conventional (e.g. 3 Tesla) fMRI. Results provided comprehensive and augmented brainstem-brain connectome to understand mechanisms of arousal-motor function in health and disease conditions and its translatability in clinical settings.

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