Abstract #3365

Functional connectome of arousal and motor brainstem nuclei using 7 Tesla resting-state fMRI in living humans

Kavita Singh¹, Simone Cauzzo^1,2, Maria Guadalupe Garcia Gomar¹, Matthew Stauder¹, Nicola Vanello³, Claudio Passino^2,4, and Marta Bianciardi¹

¹Brainstem Imaging Laboratory, Department of Radiology, Athinoula A. Martinos Center for Biomedical Imaging, Boston, MA, United States, ²Sant'Anna School of Advanced Studies, Institute of Life Sciences, Pisa, Italy, ³Dipartimento di Ingegneria dell’Informazione, University of Pisa, Pisa, Italy, ⁴Fondazione Toscana Gabriele Monasterio, Pisa, Italy

For a holistic understanding of sleep, arousal and associated motor processes, we investigated the resting-state functional connectivity of 18 arousal and motor brainstem nuclei in living humans by the use of high spatial-resolution 7 Tesla resting-state fMRI, as well as a recently developed in-vivo probabilistic atlas of these nuclei in standard space. Further, we verified the translatability of our brainstem connectome approach to conventional (e.g. 3 Tesla) fMRI. Results provided comprehensive and augmented brainstem-brain connectome to understand mechanisms of arousal-motor function in health and disease conditions and its translatability in clinical settings.

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