Abstract #3370

Where is the Pain in the Brain? Functional MRI of Saliency versus Nociception at 7.0 Tesla en route to Diagnostic Biomarkers of Pain

Gijs J. Heij^1,2, Joao Periquito¹, Haopeng Han¹, Antje Els¹, Thoralf Niendorf^1,3, and Henning M. Reimann¹

¹Berlin Ultrahigh Field Facility (B.U.F.F.), Max Delbrück Center for Molecular Medicine in the Helmholtz Association, Berlin, Germany, ²Spinoza Centre for Neuroimaging, Amsterdam, Netherlands, ³Experimental and Clinical Research Center (ECRC), a joint cooperation between the Charité Medical Faculty and the Max Delbrück Center for Molecular Medicine in the Helmholtz Association, Berlin, Germany

Identifying diagnostic biomarkers of pain is of utmost clinical importance. This is challenging since similar fMRI patterns are elicited by painful and equisalient non-painful stimuli at 3T. To decipher pain-specificity this work uses 7T high-resolution fMRI of (1) salient non-painful versus painful stimuli, (2) different types of painful stimuli in "healthy" controls versus (3) a subject with a genetically-induced pain-free phenotype. We found that canonical HRF modeling is insufficient to reliably capture the shape of elicited BOLD responses that further varied in correlation to perceived saliency.

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