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Abstract #3379

Laminar analysis of luminance-dependent visual activation in human V1 with voxel centroid mapping method

Hankyeol Lee1, Seong-Gi Kim1,2, and Kâmil Uludağ1,2,3
1Center for Neuroscience Imaging Research, Institute for Basic Science, Suwon, Korea, Republic of, 2Department of Biomedical Engineering, Sungkyunkwan University, Suwon, Korea, Republic of, 3Techna Institute & Koerner Scientist in MR Imaging, University Health Network, Toronto, ON, Canada

Luminance-dependent laminar activation analysis in human V1 is presented. White and black dot-shaped visual stimuli were used to evoke BOLD responses in the early visual cortex. Traditional on/off block stimulation paradigm and continuous stimulation paradigm without interleaved rest periods were used. With voxel centroid mapping, where each voxel’s relative cortical depth is estimated, activation ROIs across multiple image slices and subjects can be analyzed collectively with minimum smoothing and no resampling of functional data. Results show black-dominant responses in V1, with laminar profiles from continuous stimulation emphasizing the role of middle layers by minimizing the effect of ascending vein drainage.

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