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Abstract #3378

Multi-echo line-scanning for ultra-high spatiotemporal resolution: optimal settings for BOLD sensitivity enhancement

Luisa Raimondo1, Jurjen Heij1, Tomas Knapen1,2, Serge O. Dumoulin1,3, Jeroen C.W. Siero1,4, and Wietske van der Zwaag1
1Spinoza Centre for Neuroimaging, Amsterdam, Netherlands, 2VU University, Amsterdam, Netherlands, 3Experimental and Applied Psychology, VU University, Amsterdam, Netherlands, 4Radiology, University Medical Centre Utrecht, Utrecht, Netherlands

We present multi-echo line-scanning fMRI results in humans. The potential of this technique lies in the combination of both high spatial and temporal resolution while sacrificing spatial coverage outside the region of interest. We reached a 250 μm resolution along the line direction with a temporal resolution of ~100 ms. We compared BOLD sensitivity and tSNR of 5 different multi-echo acquisitions to select the optimal protocol, and three methods for echo combination. Although differences were small, the 5 echo protocol and tSNR-weighted combination were found to yield the highest BOLD sensitivity in a visual cortex ROI.

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