We present multi-echo line-scanning fMRI results in humans. The potential of this technique lies in the combination of both high spatial and temporal resolution while sacrificing spatial coverage outside the region of interest. We reached a 250 μm resolution along the line direction with a temporal resolution of ~100 ms. We compared BOLD sensitivity and tSNR of 5 different multi-echo acquisitions to select the optimal protocol, and three methods for echo combination. Although differences were small, the 5 echo protocol and tSNR-weighted combination were found to yield the highest BOLD sensitivity in a visual cortex ROI.
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