The goal of 0.1μL voxel resolution for human fMRI set by the BRAIN Initiative has thus far been nearly impossible to reach, due to the overwhelming thermal noise contribution at such high spatial resolutions. Here we show that, with the recently developed denoising algorithm NORDIC, we are able to achieve robust functional activation to visual stimuli at 0.5 mm isotropic (0.125μL) voxel resolution at 7T field strengths with only 20 minutes of data, a results that is unobtainable with conventional data reconstruction. Preliminary layer findings show a central peak, suggesting that this may dramatically improve quantification of depth-dependent activation profiles.
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