Abstract #3392

Dynamic neurometabolic and functional changes in the dorsolateral prefrontal cortex in a working memory: a combined 1H fMRS and fMRI study

Hyerin Oh^1,2, Ben Babourina-Brooks^1,2,3, Adam Berrington^2,3, Dorothee P Auer^1,2,3, Henryk Faas^1,2, and JeYoung Jung⁴

¹Division of Clinical Neuroscience, School of Medicine, University of Nottingham, Nottingham, United Kingdom, ²Sir Peter Mansfield Imaging Centre, University of Nottingham, Nottingham, United Kingdom, ³NIHR Nottingham Biomedical Research Centre, Queen’s Medical Centre, University of Nottingham, Nottingham, United Kingdom, ⁴School of Psychology, University of Nottingham, Nottingham, United Kingdom

Dynamic changes in Glx [glutamate + glutamine] and GABA concentrations were investigated in the dorsolateral prefrontal cortex (DLPFC) during a working memory using fMRS and fMRI at 3T. During the 12 minutes 2-back task Glx showed the trend of increase, while GABA levels remained stable. fMRI confirmed the increased regional activity in the DLPFC during 2-back vs. 0-back task. Importantly, the Glx changes were correlated with the DLPFC BOLD regional activity and task performance during 2-back task. Our results suggest that working memory related Glx changes may be involved in the DLPFC’s functional response and performance in working memory.

This abstract and the presentation materials are available to members only; a login is required.

Join Here