Abstract #3392

Dynamic neurometabolic and functional changes in the dorsolateral prefrontal cortex in a working memory: a combined 1H fMRS and fMRI study

Hyerin Oh^1,2, Ben Babourina-Brooks^1,2,3, Adam Berrington^2,3, Dorothee P Auer^1,2,3, Henryk Faas^1,2, and JeYoung Jung⁴

¹Division of Clinical Neuroscience, School of Medicine, University of Nottingham, Nottingham, United Kingdom, ²Sir Peter Mansfield Imaging Centre, University of Nottingham, Nottingham, United Kingdom, ³NIHR Nottingham Biomedical Research Centre, Queen’s Medical Centre, University of Nottingham, Nottingham, United Kingdom, ⁴School of Psychology, University of Nottingham, Nottingham, United Kingdom

Dynamic changes in Glx [glutamate + glutamine] and GABA concentrations were investigated in the dorsolateral prefrontal cortex (DLPFC) during a working memory using fMRS and fMRI at 3T. During the 12 minutes 2-back task Glx showed the trend of increase, while GABA levels remained stable. fMRI confirmed the increased regional activity in the DLPFC during 2-back vs. 0-back task. Importantly, the Glx changes were correlated with the DLPFC BOLD regional activity and task performance during 2-back task. Our results suggest that working memory related Glx changes may be involved in the DLPFC’s functional response and performance in working memory.

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