A gap exists in developing a sensitive method for detecting functional neuroplasticity in white matter. To investigate this, participants trained on a motor learning task for two weeks and were scanned pre and post training using task based BOLD fMRI and DTI. Low frequency oscillations in time series BOLD data demonstrated that average amplitudes decreased with training in the internal capsule and corpus callosum genu. DTI analysis detected white matter neuroplasticity in internal capsule and corona radiata using fractional anisotropy. The distributed effect of motor learning suggests that multi-modal whole brain approaches will provide a more comprehensive understanding neuroplasticity.
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