Abstract #3394

Cerebrovascular Reactivity Mapping using Resting-State Functional MRI in Patients with gliomas

Mei-Yu Yeh^1,2, Henry S Chen², Ping Hou², Vinodh A. Kumar³, Jason M Johnson³, Kyle R Noll⁴, Sujit S Prabhu⁵, Donald F. Schomer³, and Ho-Ling Liu ²

¹Department of Biomedical Engineering and Environmental Sciences, National Tsing Hua University, Hsinchu, Taiwan, ²Department of Imaging Physics, The University of Texas MD Anderson Cancer Center, Houston, Houston, TX, United States, ³Departments of Diagnostic Radiology, The University of Texas MD Anderson Cancer Center, Houston, TX, United States, ⁴Department of Neuro-oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, United States, ⁵5Department of Neurosurgery, The University of Texas MD Anderson Cancer Center, Houston, TX, United States

Clinical functional MRI (fMRI) can be limited by neurovascular uncoupling (NVU) resulted from the pathology. Cerebrovascular reactivity (CVR) mapping based on BOLD MRI during a hypercapnia task, such as breath hold (BH), has been proposed to indicate the potential NUV. However, BH-MRI is limited by patient’s corporation. Recent studies have suggested that CVR measurement can be derived from resting-state (rs) fMRI that has also been increasing utilized to map functional networks in clinical settings. This study evaluates the CVR mapping with rs-fMRI and compare with BH-MRI in patients with gliomas.

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