Abstract #3395

Long-term stability of cerebrovascular reactivity varies across brain regions

Stefano Moia^1,2, Vicente Ferrer^1,2, Rachael C Stickland³, Ross Davis Markello⁴, Eneko Uruñuela^1,2, Maite Termenon¹, César Caballero-Gaudes¹, and Molly G Bright^3,5

¹Basque Center on Cognition, Brain and Language, Donostia, Spain, ²University of the Basque Country UPV/EHU, Donostia, Spain, ³Department of Physical Therapy and Human Movement Sciences, Feinberg School of Medicine, Northwestern University, Chicago, IL, United States, ⁴Montreal Neurological Institute, McGill University, Montreal, QC, Canada, ⁵Biomedical Engineering, McCormick School of Engineering and Applied Sciences, Northwestern University, Chicago, IL, United States

The reliability of cerebrovascular reactivity varies across brain regions, but little is known about what factors drive such variability. By leveraging a high-quality precision functional mapping dataset of breath-hold induced cerebrovascular reactivity (7 subjects with 10 sessions each), we assessed how much parcellations describing different architectures (i.e. vascular anatomy, functional networks, subcortical anatomy) could present internal homogeneity, and hence explain these regionally-specific reliability. We found that all architectures taken into account can equally explain these spatial patterns of cerebrovascular reactivity.

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