Abstract #3400

Simulating the BOLD fMRI transverse relaxation at 3 T: How accurate is the 2D approximation?

Jacob Chausse¹, Avery J. L. Berman², and J. Jean Chen^1,3

¹Rotman Research Institute, Baycrest Health Sciences, North York, ON, Canada, ²A. A. Martinos Center for Biomedical Imaging, Harvard Medical School, Massachusetts General Hospital, Boston, MA, United States, ³Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada

Biophysical simulations of the BOLD fMRI phenomenon are indispensable for the development of quantitative fMRI techniques. Since the “gold-standard” 3D Monte Carlo simulation approach was proposed, 2D variations that are less computationally intensive have also been suggested. However, these approaches have never been directly compared. In this work, we directly compare the accuracy of 2D approaches against 3D ones, in order to reconcile results from different simulation studies.

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