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Abstract #3401

Realistic simulations of diffusion MR spectroscopy: The effect of glial cell swelling on non-Gaussian and anomalous diffusion

André Döring1, Maryam Afzali1, Elena Kleban1, Roland Kreis2, and Derek K Jones1
1Cardiff University Brain Research Imaging Centre (CUBRIC), Cardiff University, Cardiff, United Kingdom, 2Departments of Radiology and Biomedical Research, University of Bern, Bern, Switzerland

An existing Monte-Carlo simulation was refined to allow realistic modeling of 150x150x150μm³ tissue samples. The approach was validated on a reference sample, where ground truth is known. The non-Gaussian and anomalous diffusion behavior in diffusion MR spectroscopy experiments was modeled in realistic tissue samples composed of 30 glial cells addressing a hypothesized cell swelling evoked by glial activation. The simulated results agree well with in vivo literature values and may help to improve the linkage between diffusion and histology.

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