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Abstract #3402

Characterizing time-dependent diffusion in the extra-axonal space of white matter for axon loss and demyelination

Ricardo Coronado-Leija1, Hong-Hsi Lee1, Els Fieremans1, and Dmitry S. Novikov1
1Radiology, New York University School of Medicine, New York, NY, United States

In this work, we use Monte Carlo simulations to show how time-dependent diffusion, D(t), in the extra-axonal space provides information about the packing geometry of the axons. In particular we relate the correlation-length obtained from simulations to the correlation-length computed from the power spectrum of the axon packings. We also show through Monte Carlo simulations, in geometries of cylinders and realistic substrates, that D(t) can provide information that differentiates between axon loss and demyelination.

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