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Abstract #3403

A minimal geometrical model for Monte Carlo simulations of time dependent diffusion in axons

Henrik Lundell1 and Samo Lasič1,2
1Danish Research Centre for Magnetic Resonance, Centre for Functional and Diagnostic Imaging and Research, Copenhagen University Hospital Hvidovre, Hvidovre, Denmark, 2Random Walk Imaging, Lund, Sweden

Understanding the link between axonal geometry and diffusion is of large relevance for diffusion weighted MRI (DW-MRI) of white matter. Identifying the minimal geometrical features needed to describe time dependent diffusion allows for faster simulations adequate for the experimentally feasible level of abstraction. We propose an augmented 1D random walk model that within relevant limits mimics the time dependent diffusion in a 3D model of an axon with varying radius.

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