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Abstract #3404

Quantifying Cell Size and Membrane Permeability with Microstructure Fingerprinting

Khoi Minh Huynh1,2, Ye Wu2, and Pew-Thian Yap1,2
1Biomedical Engineering, UNC Chapel Hill, Chapel Hill, NC, United States, 2Department of Radiology and Biomedical Research Imaging Center (BRIC), UNC Chapel Hill, Chapel Hill, NC, United States

In diffusion MRI, biophysical models offer a non-invasive means of probing the tissue micro-architecture of the human brain. However, most models rely on closed-form formulas derived with simplifying assumptions such as short gradi- ent pulse, Gaussian phase distribution, and the absence of compartmental ex- change. We present a fast microstructure fingerprinting framework for accurate estimation of axon/soma radii and membrane permeability without relying on these assumptions.

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