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Abstract #3408

Impact of within-voxel heterogeneity in fibre geometry on spherical deconvolution

Ross Callaghan1, Daniel C Alexander1, Marco Palombo1, and Hui Zhang1
1Department of Computer Science and Centre for Medical Image Computing, University College London, London, United Kingdom

Axons in white matter have been shown to have varying geometries within a bundle, but what does this mean for spherical deconvolution, which assumes a single diffusion MRI (dMRI) fibre response function (FRF) for all axons within a voxel? We demonstrate, using advanced dMRI simulations, that variable fibre geometry leads to a variable FRF across axons and that a different choice of FRF can lead to large differences in the recovered fibre orientation distribution function (fODF). This finding suggests that assuming a single FRF can lead to misestimation of the fODF, causing further downstream errors in techniques such as tractography.

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