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Abstract #3409

A closer look at diffusion and fiber ODFs in a ground truth crossing fiber phantom

Steven H. Baete1,2, Patryk Filipiak1,2, Lee Basler3, Anthony Zuccolotto3, Ying-Chia Lin1,2, Dimitris G. Placantonakis4, Timothy Shepherd1,2, Walter Schneider3, and Fernando E. Boada1,2
1Center for Advanced Imaging Innovation and Research (CAI2R), NYU School of Medicine, New York, NY, United States, 2Center for Biomedical Imaging, Dept. of Radiology, NYU School of Medicine, New York, NY, United States, 3Psychology Software Tools, Inc., Pittsburgh, PA, United States, 4Department of Neurosurgery, Perlmutter Cancer Center, Neuroscience Institute, Kimmel Center for Stem Cell Biology, NYU School of Medicine, New York, NY, United States

High quality diffusion acquisitions are routinely used to study brain connectivity. In each voxel complex intra-voxel fiber crossings may be captured in Orientation Distribution Functions (ODFs). Direct comparison of ODFs calculated with different methods challenging due to a lack of ground truth. Here, we compare different q-space sampling schemes and ODF-reconstructions on a clinical 3T scanner for a known ground truth of crossing Taxons (textile water filled tubes). This comparison illustrates difficulties separating fibers crossing at less than 45° and estimating relative fiber bundle densities using conventional fiber peak identification. Use of more advanced methods is thus recommended.

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