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Abstract #3417

Lamellar liquid crystal phantom for validating MRI methods to distinguish oblate and prolate diffusion tensors on whole-body scanners

Hong Jiang1, João Pedro de Almeida Martins1, Dan Lundberg2, Chantal M. W. Tax3, and Daniel Topgaard1
1Physical Chemistry, Lund University, Lund, Sweden, 2CR Competence AB, Lund, Sweden, 3Cardiff University Brain Research Imaging Centre (CUBRIC), Cardiff University, Cardiff, United Kingdom

Conventional diffusion MRI can yield planar tensors in tissues such as epidermoid cysts, comprising tightly packed planar cells, and brain tissue "sheet" structures with populations of axonal fibers crossing at nearly right angles. The two cases may be resolved by multidimensional diffusion encoding as previously demonstrated with various liquid crystal phantoms on preclinical equipment. For method validation also on whole-body scanners, we here develop a lamellar liquid crystal phantom giving microscopically planar diffusion tensors and having sufficiently long T2 for use with single-shot EPI signal read-out.

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