Abstract #3416

Filtered water diffusion pore imaging on a 14.1T spectrometer using strong gradients and capillary phantoms in the presence of extraporal fluid

Dominik Ludwig^1,2, Frederik B. Laun³, Karel D. Klika⁴, Mark E. Ladd^1,2,5, Peter Bachert^1,2, and Tristan A. Kuder¹

¹Medical Physics in Radiology, German Cancer Research Center (DKFZ), Heidelberg, Germany, ²Faculty of Physics and Astronomy, Heidelberg University, Heidelberg, Germany, ³Institute of Radiology, University Hospital Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), Erlangen, Germany, ⁴Molecular Structure Analysis, German Cancer Research Center (DKFZ), Heidelberg, Germany, ⁵Faculty of Medicine, Heidelberg University, Heidelberg, Germany

Diffusion pore imaging (DPI) can be used to retrieve the pore space function of arbitrary closed pores. In this study, we show that DPI of glass capillaries is possible even under difficult experimental conditions. By separating the long gradient into a CPMG-like gradient echo train, matching the magnetic susceptibility and adding an additional filter diffusion weighting, it was possible to acquire diffraction patterns of glass capillaries that were placed orthogonally to the main magnetic field. Furthermore, the feasibility of doing DPI in the presence extraporal water using our filtered approach was demonstrated.

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