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Abstract #3416

Filtered water diffusion pore imaging on a 14.1T spectrometer using strong gradients and capillary phantoms in the presence of extraporal fluid

Dominik Ludwig1,2, Frederik B. Laun3, Karel D. Klika4, Mark E. Ladd1,2,5, Peter Bachert1,2, and Tristan A. Kuder1
1Medical Physics in Radiology, German Cancer Research Center (DKFZ), Heidelberg, Germany, 2Faculty of Physics and Astronomy, Heidelberg University, Heidelberg, Germany, 3Institute of Radiology, University Hospital Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), Erlangen, Germany, 4Molecular Structure Analysis, German Cancer Research Center (DKFZ), Heidelberg, Germany, 5Faculty of Medicine, Heidelberg University, Heidelberg, Germany

Diffusion pore imaging (DPI) can be used to retrieve the pore space function of arbitrary closed pores. In this study, we show that DPI of glass capillaries is possible even under difficult experimental conditions. By separating the long gradient into a CPMG-like gradient echo train, matching the magnetic susceptibility and adding an additional filter diffusion weighting, it was possible to acquire diffraction patterns of glass capillaries that were placed orthogonally to the main magnetic field. Furthermore, the feasibility of doing DPI in the presence extraporal water using our filtered approach was demonstrated.

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