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Abstract #3415

Cumulant expansions for measuring restricted diffusion and water exchange

Arthur Chakwizira1, Filip Szczepankiewicz2, Linda Knutsson1,3, Pia Sundgren2,4,5,6, and Markus Nilsson2
1Department of Medical Radiation Physics, Lund University, Lund, Sweden, 2Department of Diagnostic Radiology, Lund University, Lund, Sweden, 3Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD, United States, 4Lund University Bioimaging Center, Lund University, Lund, Sweden, 5Department for Medical Imaging and Physiology, Skåne University Hospital, Lund, Sweden, 6Department of Radiology, University of Michigan, Ann Arbor, MI, United States

Cell sizes and membrane permeability can be inferred by probing time–dependent diffusion due to restricted diffusion and water exchange. However, restriction and exchange have opposing effects on the diffusion weighted signal when varying the diffusion time, making it a challenge to disentangle the two phenomena. We explore the applicability of a unified theoretical framework that includes size and exchange in living cells by applying it to healthy and diseased human brain in vivo as well as a yeast phantom. Results highlight the potential of the framework for differentiating between healthy and abnormal tissue.

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