The IVIM model is capable of extracting functional and structural information simultaneously without the injection of contrast agents. The main limitation of this technique is the inaccuracy of the output of this model in low SNR regimes. In this study, we proposed the use of twelve diffusion imaging orientations and three b-values instead of three orthogonal DW imaging and several b-values. Simulation and in-vivo results showed that the proposed method outperforms the conventional IVIM reconstruction method. Improved quality and reproducibility can make this method more practical and attractive in clinical settings.
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