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Abstract #3436

Time-dependent and TE-dependent Diffusivity in Human Brain using Multi-TE Oscillating Gradient Spin Echo in High Gradient 3.0T MRI (MAGNUS)

Ante Zhu1, Luca Marinelli1, and Thomas K.F. Foo1
1GE Global Research, Niskayuna, NY, United States

Oscillating gradient spin echo (OGSE) diffusion imaging achieves a short diffusion time and has been performed to assess tissue characteristics at short length scale, including the correlation length of the brain tissues which may provide information on axonal beading and swelling in disease. Time-dependent diffusivity has been measured from OGSE acquisition at a fixed TE in a high-performance head-only high-gradient 3.0T MRI scanner (MAGNUS). In this study, we characterized time-dependent diffusivity at varying frequencies (0~80 Hz) and TEs (72~158 ms) using multi-TE OGSE acquisition in healthy volunteers. Preliminary results showed increased mean/parallel diffusivities in corpus callosum at shorter TE.

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