Abstract #3437

A novel clinically viable method to quantify T2 of intra and extra axonal compartmental tissue properties

Sudhir Kumar Pathak¹, Vishwesh Nath², B V Rathish Kumar³, and Walter Schneider¹

¹Psychology, University of Pittsburgh, Pittsburgh, PA, United States, ²Nvidia, Bethesda, MD, United States, ³Mathematics, Indian Institute of Technology Kanpur, Kanpur, India

Diffusion MRI based microstructural imaging is used to estimate voxel wise intra/extra-cellular volume fraction and compartment diffusivities. Previously proposed techniques like NODDI, SMT models are used to estimate intra/extra-axonal volume fraction, axial and radial diffusivity for each voxel. TEdDI is a framework to estimate intra/extra-axonal T₂ in human brain. The proposed TEdDI model requires multiple sets of diffusion dataset varies with echo time. In this study we are proposing SMT based formulation to estimate intra/extra-axonalT₂. We also used this formulation to design numerical algorithm that approximate T₂ and other parameters for a typical multi-shell diffusion acquisition.

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