In vivo diffusion MRI is by default performed using single-shot EPI with TE>50 ms and associated signal loss from transverse relaxation. The individual benefits of the current trends of increasing B0 to boost SNR and employing more advanced signal preparation schemes to improve the specificity for selected microstructural properties eventually may be cancelled by increases in relaxation rates at high B0 and TE with advanced encoding. Here, we make initial attempts to translate state-of-the-art diffusion-relaxation correlation methods to 21.1T to identify hurdles that need to be overcome to fulfill the promises of both high SNR and readily interpretable microstructural information.
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