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Abstract #3441

Application of QSM in SPIO - labeled stem cell transplantation in Beagles with acute spinal cord injury

Junting Zou1, Jilei Zhang2, Zhao Xiance2, Yuanyuan Xie1, Bing Zhang1, and Xiaoli Mai1
1Nanjing Drum Tower Hospital, Nanjing, China, 2Philips Healthcare, Shanghai, China

Tracing and monitoring the growth of transplanted stem cells in vivo has become a focus of research. The purpose of this study is to realize the dynamic tracing of transplanted mesenchymal stem cells labeled with nano-iron(SPIO-huc-MSCs), and preliminarily explore the feasibility of indirect tracing of SPIO-huc-MSCs by QSM technology. The results show that susceptibility values in the areas containing iron are significantly different from those in the normal spinal cord, which indicates that the iron concentration in the injured area decreases gradually. By quantifying iron concentration, QSM technology can be used to dynamically trace SPIO labeled stem cells in vivo.

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